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Immunohistochemical measurement and expression of Mcl-1 in infertile testes

Raafat Hegazy,Abdelmonem Hegazy,Mustafa Ammar,Emad Salem

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 361-367 doi: 10.1007/s11684-015-0395-x

Abstract: Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins involved in regulation ofThis study aimed to investigate the immunohistochemical expression of Mcl-1 in testicular biopsies ofThe specimens were subjected to immunohistochemical staining for Mcl-1 and examined through light microscopycell-only syndrome, 2 cases of basement membrane hyalinization, and 1 case of tubular and peritubular

Keywords： spermatogenesis     testis     Mcl-1 expression     immunohistochemical study     infertility    

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Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 723-735 doi: 10.1007/s11684-021-0905-y

Abstract: Among them, the expression of exosomal coronin-1a (CORO1A) was 5.3-fold higher than that in the controlsCORO1A increased with disease progression at a certain proportion in the plasma of patients with ALSCORO1A was also overexpressed in NSC-34 motor neuron-like cells, and apoptosis, oxidative stress, andautophagic protein expression were evaluated.Therefore, CORO1A might be a potential biomarker and therapeutic target for ALS.

Keywords： amyotrophic lateral sclerosis     coronin-1a     autophagy     pathogenesis    

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Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 79-86 doi: 10.1007/s11684-007-0016-4

Abstract: Results showed that compared with control groups, UVB was able to induce HIF1α and TfR protein expressionThe EGFR/PI3K/AKT signaling pathway was required for the induction of HIF-1α and TfR expression inducedUVB induced activation of EGFR in HaCat cells and EGFR regulated expression of TfR and HIF-1α.EGFR (-/-) MEF did not increase the HIF1 expression following UVB irradiation (>0.05).In contrast, EGFR (+/+) MEF strongly enhanced HIF1α expression after UVB irradiation (<0.05).
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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression andhypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolasehaploinsufficiency of Lipin3 in primary hepatocytes may induce the overexpression and abnormal distribution of Lipin1The increased expression of Lipin1 in cytosol may contribute to TG anabolism, and the decreased Lipin1in nucleoplasm can reduce PGC1α, further leading to mitochondrial dysfunction and reduced TG catabolism

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

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Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate

WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 356-358 doi: 10.1007/s11684-007-0068-5

Abstract: In the 20th week, serum lipid level and NO levels were measured, and the expression of vascular celladhesion molecule-1 (VCAM-1) and cell adhesiveness in aortic endothelia observed by computer-aided systemof VCAM-1.In fenofibrate-treated group, the expression of VCAM-1 and leukocyte accumulation on the endothelialexpression.

Keywords： endothelial     16-week treatment     leukocyte accumulation     mg/kg     NO    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Runt-related transcription factor 1 (RUNX1) is an essential regulator of normal hematopoiesis.However, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainlyHere, based on 1741 patients with AML, we report a unique expression pattern associated with RUNX1This expression pattern was coordinated by target repression and promoter hypermethylation.This study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressiveFAT1 and inhibits stemness maintenance in thyroid carcinoma

Frontiers of Medicine doi: 10.1007/s11684-023-0999-5

Abstract: Further, Pearson’s correlation coefficient revealed a positive correlation between GTF2I expression andFAT1 expression.The under-expression of GTF2I and FAT1 was validated in TC cell lines.its expression.stemness maintenance by increasing the expression of FAT1 and facilitating the FAT1-mediated CDK4/FOXM1

Keywords： thyroid carcinoma     mesenchymal stem cell     extracellular vesicle     GTF2I     FAT1     CDK4    

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APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: MdSIZ1 is a SUMO (small ubiquitin-like modifier) E3 ligase that promotes SUMO binding to substrate proteinsHere, we demonstrate that MdSIZ1 in apple has a negative relationship with drought tolerance MdSIZ1 RNAi transgenic apple trees had a higher survival rate after drought stress.In addition, MdSIZ1 RNAi transgenic plants had a higher net photosynthetic rate duringFinally, the transgenic apple trees also altered expression levels of some microRNAs in response to drought

Keywords： apple / drought tolerance / gene expression / MdSIZ1    

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High-level expression of recombinant IgG1 by CHO K1 platform

Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3,   Pages 376-380 doi: 10.1007/s11705-015-1531-5

Abstract: The Chinese Hamster Ovary (CHO K1) cell was used to express a targeted anti-cancer monoclonal antibodyThe adherent CHO K1 was first adapted to suspension culture in chemical defined medium.synthetase (GS) vector was applied to construct a single plasmid to overexpress a monoclonal antibody IgG1.The best cell pool of CHO K1/IgG1 was used to screen the top single clone using the limiting dilutionFinally, a high IgG1 production of 780 mg/L was obtained from a batch culture.

Keywords： Chinese hamster ovary (CHO)     monoclonal antibody     IgG1     amplification     cell line development    

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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 61-66 doi: 10.1007/s11684-009-0007-8

Abstract: The aim of this study was to explore the regulatory mechanism of retinoic acid (RA) on the TBX1 geneexpression in myocardial cells.There was basal expression of Shh and Fgf8 in the control group.At the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1expression.

Keywords： retinoic acid     Tbx1 protein     Shh protein     Fgf8 protein    

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 36-40 doi: 10.1007/s11684-009-0020-y

Abstract: of angiotensin receptor type 1 (AT1R) in hepatic stellate cells (HSCs)The mRNA expression of AT1R at 4, 12 and 24 h after treatment was detected by reverse transcription-polymeraseThe protein expression of AT1R was detected by western blot.The expression of AT1R protein also decreased after the treatment with β-elemene for 24 h. β-elemenecan inhibit the secretion of ANG II and the gene and protein expression of AT1R, which may be the mechanism

Keywords： liver cirrhosis     beta-elemene     hepatic stellate cells     angiotensin II     receptor     angiotensin     type 1    

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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressioncells with different gene expression levels, including insulin receptor substrate-1(IRS-1), phosphatidylinositolThe glucose uptake decreased with the increase in gene expression in 3T3-L1 cells, which was independentThe mRNA expression of two signal proteins PI-3K and AKT-2 decreased and the other two signal proteins, GSK-3 and p38MAPK, increased with overexpression in 3T3-L1 cells.

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine modelThe relative gene expression level of PAR-1 was significantly increased in the skin, liver, small intestinePAR-1, 2 protein expression was in accordance with the mRNA expression, as shown by Western blot.Our findings of markedly increased expression of PAR-1, 2 in target organs of acute GVHD suggest thatPAR-1 and PAR-2 may play an important role in the pathogenesis of acute GVHD.

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

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Developmental expression of CAPON and Dexras1 in spinal cord of rats

LI Xin, CHENG Chun, CHEN Mengling, GAO Shangfeng, ZHAO Jian, NIU Shuqiong, SHEN Aiguo

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 75-81 doi: 10.1007/s11684-008-0014-1

Abstract: To study the expression of the carboxy-terminal PSD-95/DLG/ZO-1 ligand of nNOS (CAPON) and Dexras1 mRNApolymerase chain reaction (Real-time PCR), as a quantitative method, was used to study the developmental expressionThe spatial expression of CAPON and Dexras1 mRNA was examined by a combination of hybridization (ISHSpatiotemporal expression of Dexras1 mRNA was similar to CAPON as confirmed by correlation analysis andCo-expression of CAPON and Dexras1 mRNA in myeloid tissue during development process of rat indicates

Keywords： CAPON     ISH     differentiation     postnatal     different subcellular    

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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: The aim of this study was to explore the expression of integrin-β1 in different stages of hepatic fibrosisThe expression of integrin-β1, tumor growth factor-β (TGF-β) and tissue inhibitor of metalloproteinaseThe expression of integrin-β1, TGF-β and TIMP-1 was determined in each group.The expression of integrin-β1 in normal control group was low and steady and was not increased as theThe expression of TGF-β and TIMP-1 was consistent with that of integrin-β1 in different stages of hepatic

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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Title Author Date Type Operation

Immunohistochemical measurement and expression of Mcl-1 in infertile testes

Raafat Hegazy,Abdelmonem Hegazy,Mustafa Ammar,Emad Salem

Journal Article

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

Journal Article

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression andhypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

Journal Article

Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate

WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressiveFAT1 and inhibits stemness maintenance in thyroid carcinoma

Journal Article

APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Journal Article

High-level expression of recombinant IgG1 by CHO K1 platform

Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu

Journal Article

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Journal Article

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Journal Article

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

Developmental expression of CAPON and Dexras1 in spinal cord of rats

LI Xin, CHENG Chun, CHEN Mengling, GAO Shangfeng, ZHAO Jian, NIU Shuqiong, SHEN Aiguo

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article